BDBM363487 (1R,2'R,5S)-8-((R)-2-hydroxy-2- (4-methyl-1-oxo-1,3- dihydroisobenzofuran-5- yl)ethyl)-4'-(5-oxo-2,5- dihydrofuran-3-yl)-8- azaspiro[bicyclo[3.2.1]octane- 3,2'-morpholin]-3'-one::US9850245, Example 36
SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1C2CCC1CC1(C2)OCCN(C2=CC(=O)OC2)C1=O
InChI Key InChIKey=DDLUZUNMJPBUAE-VSZVXJMPSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 363487
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 13.4nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair