BDBM385490 4-((R or S)-1-(2-chloro-6-(1- (trifluoromethyl)cyclopropyl) benzoyl)-6-((R)-3- cyanopyrrolidine-1- carbonyl)-4,5,6,7- tetrahydro-1H-indazol- 3-yl)cyclohex-3-ene-1- carboxylic acid::US10287272, Example 5II::US10689369, Example 5II

SMILES OC(=O)C1CCC(=CC1)c1nn(C(=O)c2c(Cl)cccc2C2(CC2)C(F)(F)F)c2CC(CCc12)C(=O)N1CC[C@H](C1)C#N

InChI Key InChIKey=GCHHPSPUFDRDCR-KKXNLOMOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385490   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385490(4-((R or S)-1-(2-chloro-6-(1- (trifluoromethyl)cyc...)
Affinity DataIC50:  1nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385490(4-((R or S)-1-(2-chloro-6-(1- (trifluoromethyl)cyc...)
Affinity DataIC50:  1nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent