BDBM392705 3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)phenyl)-1H-pyrazol-5-yl)ureido)-naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-methoxy-N-(2-(2-(2-methoxyethoxy)-ethoxy)ethyl)benzamide::US10301288, Example 16

SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1

InChI Key InChIKey=JTZCPHYRKRLLIF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 392705   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM392705(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Affinity DataIC50:  15nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM392705(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Affinity DataIC50:  646nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Topivert Pharma

US Patent
LigandPNGBDBM392705(3-((4-((4-(3-(3-(tert-Butyl)-1-(4-(dimethylamino)p...)
Affinity DataIC50:  27nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent