BDBM394161 5-[5-chloro-2- (1H-tetrazol- 1-yl)phenyl]- 2-[(1S)-1-{3- [1-(oxetan-2- ylcarbonyl) piperidin-4- yl]phenyl}-2- phenylethyl] pyridine 1- oxide::US9975874, Example 35

SMILES Clc1ccc(c(c1)-c1ccc([nH+]c1)[C@@H](Cc1ccccc1)c1cccc(c1)C1CCN(CC1)C(=O)C1CCO1)-n1cnnn1

InChI Key InChIKey=FGNYZFBGTYKJNE-LUWJBUJKSA-O

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394161   

TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394161(5-[5-chloro-2- (1H-tetrazol- 1-yl)phenyl]- 2-[(1S)...)
Affinity DataIC50:  403nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394161(5-[5-chloro-2- (1H-tetrazol- 1-yl)phenyl]- 2-[(1S)...)
Affinity DataIC50:  12.2nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent