BDBM394169 2-fluoroethyl 4-{3-[(1S)-1- {5-[5-chloro-2- (1H-tetrazol- 1-yl)phenyl]- 1- oxidopyridin- 2-yl}-2- phenylethyl] phenyl} piperidine- 1-carboxylate::US9975874, Example 43

SMILES [O-][n+]1cc(ccc1[C@@H](Cc1ccccc1)c1cccc(c1)C1CCN(CC1)C(=O)OCCF)-c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=HWIBNEIFJJXLAX-PMERELPUSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 394169   

TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394169(2-fluoroethyl 4-{3-[(1S)-1- {5-[5-chloro-2- (1H-te...)
Affinity DataIC50:  63.4nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent