BDBM408041 US10336774, Example 10b::US10336774, Example 11b

SMILES N[C@@H]1CC[C@@]11CCN(C1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=JQHLHGLCNZMOSG-PXAZEXFGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408041   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM408041(US10336774, Example 10b | US10336774, Example 11b)
Affinity DataIC50:  145nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM408041(US10336774, Example 10b | US10336774, Example 11b)
Affinity DataIC50:  189nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent