BDBM408054 US10336774, Example 22

SMILES N[C@H]1CCC11CCN(CC1)c1nc(N)c(Sc2cccnc2C(F)(F)F)nc1C(N)=O

InChI Key InChIKey=NAIWLOCQHRHCQJ-NSHDSACASA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 408054   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM408054(US10336774, Example 22)
Affinity DataIC50:  53nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent