BDBM426677 1-(3-(5-amino-6-(2-fluoro-4-((4-(trifluoro- methyl)pyridin-2-yl)oxy)phenyl)quinazolin-8- yl)pyrrolidin-1-yl)prop-2-en-1-one::US10544106, Compound C195::US11208388, Example 197

SMILES Nc1c(cc(C2CCN(C2)C(=O)C=C)c2ncncc12)-c1ccc(Oc2cc(ccn2)C(F)(F)F)cc1F

InChI Key InChIKey=YNRREUJYSUDDCE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426677   

TargetTyrosine-protein kinase BTK(Human)
Neupharma

US Patent
LigandPNGBDBM426677(1-(3-(5-amino-6-(2-fluoro-4-((4-(trifluoro- methyl...)
Affinity DataIC50: 100nMAssay Description:To determine IC50 of a compound against a kinase, a series of concentrations of the compound were tested for the inhibition. IC50 was calculated by p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Neupharma

US Patent
LigandPNGBDBM426677(1-(3-(5-amino-6-(2-fluoro-4-((4-(trifluoro- methyl...)
Affinity DataIC50: 100nMAssay Description:To determine IC50 of a compound against a kinase, a series of concentrations of the compound were tested for the inhibition. IC50 was calculated by p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent