BDBM434879 US10583137, Compound 17::tert-Butyl 3-benzyl-4-(4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carbonyl)piperazine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCN(C(Cc2ccccc2)C1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=CQGMWUWJVBKTRM-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 434879   

TargetDiacylglycerol lipase-alpha(Homo sapiens (Human))
The Scripps Research Institute

US Patent
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: <400nMAssay Description:Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDiacylglycerol lipase-beta(Homo sapiens (Human))
The Scripps Research Institute

US Patent
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: <400nMAssay Description:Briefly, membrane proteome (1 mg/ml, 20 μL) was prepared from HEK293T cells (transiently transfected with hDAGLα-FLAG or hDAGLα-S472A-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDiacylglycerol lipase-beta(Mus musculus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol lipase-beta(Mus musculus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of mouse DAGLbeta expressed in HEK293T cell membranes using SAG as substrate preincubated for 30 mins followed by substrate addition by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Mus musculus (mouse))TBA
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50:  79nMAssay Description:Inhibition of ABHD6 in mouse brain membrane using HT-01 probe as substrate incubated for 30 mins by gel based competitive ABPP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDiacylglycerol lipase-beta(Mus musculus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of mouse DAGLbeta expressed in HEK293T cell membranes using SAG as substrate preincubated for 30 mins followed by substrate addition by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol lipase-alpha(Homo sapiens (Human))
The Scripps Research Institute

US Patent
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50:  0.501nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol lipase-beta(Mus musculus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoacylglycerol lipase ABHD6(Homo sapiens (Human))TBA
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human recombinant ABHD6More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDiacylglycerol lipase-alpha(Homo sapiens (Human))
The Scripps Research Institute

US Patent
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50:  0.501nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed