BDBM436104 4-(((3S,4R)-1- ((2-cyano-4- (trifluoromethyl) phenyl)sulfonyl)- 4-hydroxy-4- (hydroxymethyl) pyrrolidin-3- yl)methyl)-2- fluorobenzonitrile::US10590077, Example 5

SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(cc1C#N)C(F)(F)F

InChI Key InChIKey=RDXAJICEALUQOJ-FXAWDEMLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436104   

TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436104(4-(((3S,4R)-1- ((2-cyano-4- (trifluoromethyl) phen...)
Affinity DataIC50:  5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent