BDBM436105 4-(((3S,4R)-1- ((2-chloro-4- cyanophenyl) sulfonyl)-4- hydroxy-4- (hydroxymethyl) pyrrolidin-3- yl)methyl)-2- fluorobenzonitrile::US10590077, Example 6

SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(cc1Cl)C#N

InChI Key InChIKey=ZLSYCTPUNQODSG-OXJNMPFZSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436105   

TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436105(4-(((3S,4R)-1- ((2-chloro-4- cyanophenyl) sulfonyl...)
Affinity DataIC50:  5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent