BDBM446688 US10669289, Compound 95::[(1R)-1-[[2-(3,5-dichloro-N-prop-2-enoyl-anilino)acetyl]amino]-2-(3-thienyl)ethyl]boronic Acid (Compound No. 95)

SMILES OB(O)[C@H](Cc1ccsc1)NC(=O)CN(C(=O)C=C)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=FAYNMTTYEQPHKN-HNNXBMFYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 446688   

TargetProteasome subunit beta type-5(Human)
Merck Patent

US Patent
LigandPNGBDBM446688(US10669289, Compound 95 | [(1R)-1-[[2-(3,5-dichlor...)
Affinity DataIC50: >5.00E+3nMAssay Description:Measurement of Beta5 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human constitutive proteasome (1.25 nM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProteasome subunit beta type-8(Human)
Merck Patent

US Patent
LigandPNGBDBM446688(US10669289, Compound 95 | [(1R)-1-[[2-(3,5-dichlor...)
Affinity DataIC50: <50nMAssay Description:Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immuno proteasome (0.25 nM) and s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent