BDBM470680 (S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-fluoro-5-methyl-N-(thiazol-4-yl)benzenesulfonamide formate::US10815229, Example 101

SMILES CN([C@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=UCSHINHOAVARGQ-SFHVURJKSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 470680   

TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM470680((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Affinity DataIC50:  272nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM470680((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Affinity DataIC50:  2.43E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM470680((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Affinity DataIC50:  3.17E+4nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM470680((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Affinity DataIC50:  54nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM470680((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Affinity DataIC50: >3.00E+4nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM470680((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Affinity DataIC50:  1.56E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In DepthDetails US Patent