BDBM480516 6-fluoro-5-(1-(4-(1-(2-methoxy ethyl)-1H-pyrazol-4-yl)phenyl)piperidin-4-yl)-5H-imidazo[5,1-a]isoindole trifluoroacetate::US10899764, Example 42

SMILES COCCn1cc(cn1)-c1ccc(cc1)N1CCC(CC1)C1c2c(cccc2F)-c2cncn12

InChI Key InChIKey=XANOGKVQLSCDIR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480516   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480516(6-fluoro-5-(1-(4-(1-(2-methoxy ethyl)-1H-pyrazol-4...)
Affinity DataIC50: 36.3nMAssay Description:IDO1: For testing, 24 μL of enzyme (IDO1) was diluted 100 times with 50 mM KPB to 2400 μL. The concentration of the enzyme solution was 2.6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480516(6-fluoro-5-(1-(4-(1-(2-methoxy ethyl)-1H-pyrazol-4...)
Affinity DataIC50: 217nMAssay Description:TDO: For testing, 24 μL of enzyme (TDO) was diluted 100 times with 50 mM KPB to 2400 μL. The concentration of the enzyme solution was 2.6 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent