BDBM481200 6-((5S,8R)-2-(5-Fluoropyridin-2-yl)-5,6,7,8-tetrahydro-5,8-methanoimidazo[1,2-a]pyrid in-3-yl)quinoline-4-carboxamide 39-1::US10906905, Example 39-1

SMILES NC(=O)c1ccnc2ccc(cc12)-c1c(nc2[C@@H]3CC[C@@H](C3)n12)-c1ccc(F)cn1

InChI Key InChIKey=IMNHEZQIZVJYRU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481200   

TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481200(6-((5S,8R)-2-(5-Fluoropyridin-2-yl)-5,6,7,8-tetrah...)
Affinity DataIC50: 26nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481200(6-((5S,8R)-2-(5-Fluoropyridin-2-yl)-5,6,7,8-tetrah...)
Affinity DataIC50: 4.73E+3nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481200(6-((5S,8R)-2-(5-Fluoropyridin-2-yl)-5,6,7,8-tetrah...)
Affinity DataIC50: 6.31E+3nMAssay Description:VEGFR2: Z′-LYTE Kinase Assay Kit Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEGF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent