BDBM50015370 CHEMBL3264599::US9150527, 2

SMILES COc1cc2ccc(cc2cc1OC)C(O)(C(C)C)c1cncs1

InChI Key InChIKey=RBHSEBMDGMNLDP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50015370   

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rat)
Viamet Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50015370(CHEMBL3264599 | US9150527, 2)
Affinity DataIC50: 290nMAssay Description:Inhibition of rat testicular microsome CYP17 lyase activity using 17alpha-hydroxypregnenolone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Innocrin Pharmaceuticals

US Patent
LigandPNGBDBM50015370(CHEMBL3264599 | US9150527, 2)
Affinity DataIC50: 290nMAssay Description:CYP17 activity was assayed according to the following procedure. Solutions of each test compound and isozyme inhibitor (ketoconazole) were separately...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Innocrin Pharmaceuticals

US Patent
LigandPNGBDBM50015370(CHEMBL3264599 | US9150527, 2)
Affinity DataIC50: 770nMAssay Description:CYP17 activity was assayed according to the following procedure. Solutions of each test compound and isozyme inhibitor (ketoconazole) were separately...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Innocrin Pharmaceuticals

US Patent
LigandPNGBDBM50015370(CHEMBL3264599 | US9150527, 2)
Affinity DataIC50: 770nMAssay Description:Inhibition of human hepatocyte microsome CYP3A4 using testosterone as substrate by HPLC/MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Innocrin Pharmaceuticals

US Patent
LigandPNGBDBM50015370(CHEMBL3264599 | US9150527, 2)
Affinity DataIC50: 3.00E+3nMAssay Description:CYP17 activity was assayed according to the following procedure. Solutions of each test compound and isozyme inhibitor (ketoconazole) were separately...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Innocrin Pharmaceuticals

US Patent
LigandPNGBDBM50015370(CHEMBL3264599 | US9150527, 2)
Affinity DataIC50: 3.30E+4nMAssay Description:CYP17 activity was assayed according to the following procedure. Solutions of each test compound and isozyme inhibitor (ketoconazole) were separately...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent