BDBM50059307 CHEMBL3393439::US9156845, 1
SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCOCC3)c12
InChI Key InChIKey=VNWKCLDQBNSJJO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50059307
Affinity DataIC50: 13nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer
US Patent
Pfizer
US Patent
Affinity DataIC50: 36nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of GST-tagged truncated human recombinant LRRK2 using fluorescein-labeled LRRKtide peptide substrate incubated for 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 278nMAssay Description:Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELI...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of GST-tagged truncated human recombinant LRRK2 G2019S mutant using fluorescein-labeled LRRKtide peptide substrate incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of LRRK2 in human PBMCs by ActivX KiNativ methodMore data for this Ligand-Target Pair