BDBM50063418 4-{2-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-(2-methoxy-ethyl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide::CHEMBL171097

SMILES COCC[C@H]1CN(CCN1C(=O)CC1CCN(CC1)C(N)=O)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12

InChI Key InChIKey=JXRQSWZVIHDLQO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50063418   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063418(4-{2-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benz...)
Affinity DataIC50: 92nMAssay Description:In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogeneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063418(4-{2-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benz...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Farnesyltransferase from Ras-CVLS or Ras-CVLL in Cos-7 monkey kidney cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed