BDBM50082356 4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-p-tolyloxy-5H-furan-2-one::CHEMBL107088

SMILES Cc1ccc(OC2=C(c3ccc(cc3)S(C)(=O)=O)C(C)(C)OC2=O)cc1

InChI Key InChIKey=ILKNRFAZXMWVEA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50082356   

TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082356(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-p-toly...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082356(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-p-toly...)
Affinity DataIC50: 40nMAssay Description:In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082356(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-p-toly...)
Affinity DataIC50: 300nMAssay Description:In vitro inhibitory potency against U-937 microsomal COX-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed