BDBM50082358 4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(5-methyl-pyridin-2-yloxy)-5H-furan-2-one::CHEMBL320111

SMILES Cc1ccc(OC2=C(c3ccc(cc3)S(C)(=O)=O)C(C)(C)OC2=O)nc1

InChI Key InChIKey=HPIHVVAXNOHCLX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50082358   

TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082358(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(5-met...)
Affinity DataIC50: 150nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082358(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(5-met...)
Affinity DataIC50: 380nMAssay Description:Inhibitory potency against PGE-2 production in the human whole blood (HWB COX-2) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082358(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(5-met...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed