BDBM50092240 5-[4-(3-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::CHEMBL433097

SMILES CC(C)(C)n1cc(-c2ccc(Oc3cccc(N)c3)cc2)c2c(N)ncnc12

InChI Key InChIKey=OSYIMIXLSSLOOL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50092240   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092240(5-[4-(3-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092240(5-[4-(3-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50:  15nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092240(5-[4-(3-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50: <3nMAssay Description:Inhibition of p56 Lck tyrosine kinase (catalytic domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092240(5-[4-(3-Amino-phenoxy)-phenyl]-7-tert-butyl-7H-pyr...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against tie-2 at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed