BDBM50092246 4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid::CHEMBL305748

SMILES Nc1ncnc2n(C3CCCC3)c(C(O)=O)c(-c3ccc(Oc4ccccc4)cc3)c12

InChI Key InChIKey=FPIOJWKCVYGQDH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50092246   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092246(4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...)
Affinity DataIC50:  9.82E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (VEGFR2) at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092246(4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against p56 Lck tyrosine kinase at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Basf Bioresearch

Curated by ChEMBL
LigandPNGBDBM50092246(4-Amino-7-cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrr...)
Affinity DataIC50:  410nMAssay Description:Inhibitory activity against tie-2 at a concentration of 5 microM ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed