BDBM50098388 2-(4-aminophenyl)-1-hydroxy-ethane-1,1-bisphosphonate::2-(4-aminophenyl)-1-hydroxyethane-1,1-diyldiphosphonic acid::CHEMBL417932::[2-(4-Amino-phenyl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acid

SMILES Nc1ccc(CC(O)(P(O)(O)=O)P(O)(O)=O)cc1

InChI Key InChIKey=BRTBLZVYDKNGQX-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50098388   

TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098388(2-(4-aminophenyl)-1-hydroxyethane-1,1-diyldiphosph...)
Affinity DataKi:  4.20E+3nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098388(2-(4-aminophenyl)-1-hydroxyethane-1,1-diyldiphosph...)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098388(2-(4-aminophenyl)-1-hydroxyethane-1,1-diyldiphosph...)
Affinity DataIC50: 4.37E+4nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME (M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetH(+)-exporting diphosphatase(Trypanosoma brucei)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098388(2-(4-aminophenyl)-1-hydroxyethane-1,1-diyldiphosph...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei soluble vacuolar pyrophosphatase expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098388(2-(4-aminophenyl)-1-hydroxyethane-1,1-diyldiphosph...)
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed