BDBM50099261 6-Fluoro-3-(4-fluoro-piperidin-3-yl)-1H-indole-2-carboxylic acid methyl ester::CHEMBL288447

SMILES COC(=O)c1[nH]c2cc(F)ccc2c1C1CNCC[C@H]1F

InChI Key InChIKey=CJPSOUOLAPMNQT-RRKGBCIJSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50099261   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099261(6-Fluoro-3-(4-fluoro-piperidin-3-yl)-1H-indole-2-c...)
Affinity DataKi:  10.4nMAssay Description:Ability to displace [3H]-ketanserin binding to human 5-hydroxytryptamine 2A receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099261(6-Fluoro-3-(4-fluoro-piperidin-3-yl)-1H-indole-2-c...)
Affinity DataKi: >1.60E+3nMAssay Description:Ability to displace [3H]-spiperone binding to CHO cells stably expressing dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099261(6-Fluoro-3-(4-fluoro-piperidin-3-yl)-1H-indole-2-c...)
Affinity DataKi: >2.00E+3nMAssay Description:Ability to displace [3H]-mesulergine binding to human 5-hydroxytryptamine 2C receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099261(6-Fluoro-3-(4-fluoro-piperidin-3-yl)-1H-indole-2-c...)
Affinity DataKi:  8.20E+3nMAssay Description:Displacement of [3H]-dofetilide from HEK cells expressing hERG voltage dependent IKr potassium channel Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099261(6-Fluoro-3-(4-fluoro-piperidin-3-yl)-1H-indole-2-c...)
Affinity DataKi:  8.20E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed