BDBM50099994 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)-2-(naphthalen-2-yloxy)benzonitrile::4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-(naphthalen-2-yloxy)-benzonitrile::CHEMBL31828

SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4ccccc4c3)c2)CC1=O

InChI Key InChIKey=VRSNOOISIRFSDW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50099994   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099994(4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)met...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50099994(4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)met...)
Affinity DataIC50:  1.99E+5nMAssay Description:In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099994(4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)met...)
Affinity DataIC50:  48nMAssay Description:Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed