BDBM50113416 5-[1-(4-Chloro-phenyl)-2-pyridin-4-yl-ethyl]-2,3-bis-difluoromethoxy-pyridine 1-oxide::CHEMBL284852

SMILES [O-][n+]1cc(cc(OC(F)F)c1OC(F)F)C(Cc1ccncc1)c1ccc(Cl)cc1

InChI Key InChIKey=WRBBAAICBLTVQL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50113416   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50113416(5-[1-(4-Chloro-phenyl)-2-pyridin-4-yl-ethyl]-2,3-b...)
Affinity DataIC50: 32nMAssay Description:Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50113416(5-[1-(4-Chloro-phenyl)-2-pyridin-4-yl-ethyl]-2,3-b...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibitory concentration of compound against LPS- induced TNF-alpha production in whole human blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed