BDBM50121374 CHEMBL3622117

SMILES COc1cc(ccn1)N1CCC(CC1)Nc1ncc2OCCN(c3ccccc3)c2n1

InChI Key InChIKey=XACONTOQPBZMQC-UHFFFAOYSA-N

Data  1 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50121374   

TargetPresenilin-1(Homo sapiens (Human))
Forum Pharmaceuticals

Curated by ChEMBL

LigandBDBM50121374(CHEMBL3622117)Copy SMILESCopy InChI

Affinity DataEC50:  25nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human APP751 assessed as reduction in amyloid beta 42 production after 16 to 18 hrs by san...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL

LigandBDBM50121374(CHEMBL3622117)Copy SMILESCopy InChI

Affinity DataIC50:  25nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing human wild type APP75I cDNA assessed as reduction in amyloid beta peptides incubated for 1...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI