BDBM50151599 8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-(1'',2'',3'',4''-tetrahydroquinazoline)]-2''-one::CHEMBL361469

SMILES Clc1cc(cc2c1NC(=O)NC21CCCCC1)-c1ccccn1

InChI Key InChIKey=YLAZOYMBIIKPOA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50151599   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151599(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50:  6.84E+4nMAssay Description:In vitro inhibition of human Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151599(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50:  8.30E+3nMAssay Description:In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151599(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151599(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50:  1.80E+3nMAssay Description:In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151599(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)
Affinity DataIC50:  4.51E+4nMAssay Description:In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed