BDBM50180453 (3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine::CHEMBL202970

SMILES COc1cc2CNc3c(Nc4ccc(F)c(Cl)c4)ncnc3Oc2cc1OC

InChI Key InChIKey=PIRRCCINNCBLGG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50180453   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50180453((3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)
Affinity DataIC50:  690nMAssay Description:Inhibition of EGFR autophosphorylation in DiFi cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50180453((3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50180453((3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of KDR measured as pGAT-biotin peptide phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50180453((3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of EGFR measured as pGAT-biotin peptide phosphorylation in presence of 2.0 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Imclone Systems

Curated by ChEMBL
LigandPNGBDBM50180453((3-Chloro-4-fluoro-phenyl)-(7,8-dimethoxy-10,11-di...)
Affinity DataIC50:  700nMAssay Description:Inhibition of EGFR autophosphorylation in DiFi cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed