BDBM50186624 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide::CHEMBL377085

SMILES Cc1cc(C)c2c(N)c(sc2n1)C(N)=O

InChI Key InChIKey=SDMLKCQDZJOSDN-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50186624   

TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of IKK alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of IKK betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of Flag epitope-tagged IKK-beta preincubated for 5 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186624(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbox...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed