BDBM50190553 1-[2-(trityloxy)ethoxymethyl]uracil::CHEMBL424704::US8530490, Comparative 1

SMILES O=c1ccn(COCCOC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]1

InChI Key InChIKey=QEKAGWDUKXATPZ-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50190553   

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50190553(1-[2-(trityloxy)ethoxymethyl]uracil | CHEMBL424704...)
Affinity DataKi:  700nMAssay Description:Inhibition of Plasmodium falciparum dUTPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50190553(1-[2-(trityloxy)ethoxymethyl]uracil | CHEMBL424704...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human recombinant dUTPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50190553(1-[2-(trityloxy)ethoxymethyl]uracil | CHEMBL424704...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human dUTPase using dUTP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50190553(1-[2-(trityloxy)ethoxymethyl]uracil | CHEMBL424704...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50190553(1-[2-(trityloxy)ethoxymethyl]uracil | CHEMBL424704...)
Affinity DataIC50:  1.85E+5nMAssay Description:The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-...More data for this Ligand-Target Pair
In DepthDetails US Patent