BDBM50202250 CHEMBL3937333

SMILES COc1ccc2[nH]cc(CCNC(=O)c3cc(=O)c4c(OCc5ccccc5F)cccc4o3)c2c1

InChI Key InChIKey=IPGDJFIGRFRZRW-UHFFFAOYSA-N

Data  2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50202250   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lyon 1

Curated by ChEMBL

LigandBDBM50202250(CHEMBL3937333)Copy SMILESCopy InChI

Affinity DataEC50:  550nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as reduction in mitoxantrone efflux after 30 mins by flow cytometric analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/3/2018
Entry Details Article
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TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lyon 1

Curated by ChEMBL

LigandBDBM50202250(CHEMBL3937333)Copy SMILESCopy InChI

Affinity DataEC50:  5.50E+8nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as increase in mitoxantrone accumulation incubated for 30 mins by flow cytome...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/25/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL