BDBM50239548 CHEMBL4080523

SMILES COCCNCc1cccc(Cc2c(cc3scc(C)n3c2=O)[C@H](C)Nc2ncnc(N)c2C#N)c1

InChI Key InChIKey=NFPBZMLIFXRGDV-KRWDZBQOSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50239548   

LigandPNGBDBM50239548(CHEMBL4080523)
Affinity DataIC50:  398nMAssay Description:Inhibition of recombinant human His6-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 15 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239548(CHEMBL4080523)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PI3Kdelta in human JeKo1 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 60 mins followed by Anti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239548(CHEMBL4080523)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239548(CHEMBL4080523)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239548(CHEMBL4080523)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human His6-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 15 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed