BDBM50243975 CHEMBL4080226

SMILES COc1cc(N2CC[C@@H](Oc3ccc(cc3)N3N=C([C@@H](C)[C@@H]3CC(O)=O)C(F)(F)F)[C@H](C)C2)c(Cl)cn1

InChI Key InChIKey=GKIUHMMLGAMMOO-UHFFFAOYSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50243975   

TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50243975(CHEMBL4080226)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50243975(CHEMBL4080226)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50243975(CHEMBL4080226)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50243975(CHEMBL4080226)
Affinity DataEC50:  3.60E+3nMAssay Description:Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50243975(CHEMBL4080226)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50243975(CHEMBL4080226)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50243975(CHEMBL4080226)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50243975(CHEMBL4080226)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50243975(CHEMBL4080226)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed