BDBM50246776 3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyrrolo[3',4':2,3][1,4]diazepino[1,7-a]indol-2-yl)propyl N-Methylimidothiocarbamate::CHEMBL488271

SMILES CN=C(N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O

InChI Key InChIKey=MTYBEFAXRMHIIW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50246776   

TargetInsulin receptor(Homo sapiens (Human))
Institute Of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246776(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of human INSRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Institute Of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246776(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of human ARK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Institute Of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246776(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human CDK4/CycD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Institute Of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246776(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human EPHB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Institute Of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246776(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of human METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Institute Of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246776(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of human PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Institute Of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246776(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Institute Of General Genetics

Curated by ChEMBL
LigandPNGBDBM50246776(3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyr...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of human CDK2/Cyc2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed