BDBM50248604 (3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl)methanone::CHEMBL460545::US9139546, 28

SMILES Oc1cc(cc(O)c1-c1cc(Cl)cc(Cl)c1)C(=O)c1ccccc1

InChI Key InChIKey=CRNLOOZHRPDURJ-UHFFFAOYSA-N

Data  8 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50248604   

TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  2.94nMAssay Description:Binding affinity to human CB2 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  2.94nM ΔG°:  -11.8kcal/moleT: 2°CAssay Description:Cell membranes from HEK293 cells transfected with the human CB1 receptor and membranes from CHO-K1 cells transfected with the human CB2 receptor were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  27nMAssay Description:Binding affinity to human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  27nM ΔG°:  -10.5kcal/moleT: 2°CAssay Description:Cell membranes from HEK293 cells transfected with the human CB1 receptor and membranes from CHO-K1 cells transfected with the human CB2 receptor were...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  121nMAssay Description:Displacement of [3H]-CP55940 from CB2 receptor (unknown origin) expressed in CHO cell membranes after 90 mins by liquid scintillation counting analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  121nMAssay Description:Displacement of [3H]-CP55940 from human recombinant cannabinoid CB2 receptor expressed in HEK cell membranes incubated for 1.5 hrs by liquid scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  4.78E+3nMAssay Description:Displacement of [3H]-CP55940 from human recombinant cannabinoid CB1 receptor expressed in HEK cell membranes incubated for 1.5 hrs by liquid scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  4.78E+3nMAssay Description:Displacement of [3H]-CP55940 from CB1 receptor (unknown origin) expressed in CHO cell membranes after 90 mins by liquid scintillation counting analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataEC50:  155nMAssay Description:Inverse agonist activity at cannabinoid CB2 receptor in human U2OS cells assessed as induction of beta-arrestin recruitment using CCF4/AM as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataEC50:  155nMAssay Description:Inverse agonist activity at human recombinant cannabinoid CB2 receptor expressed in HEK cells transfected with CNG assessed as increase in cAMP level...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataEC50:  153nMAssay Description:Inverse agonist activity at CB2 receptor (unknown origin) expressed in HEK cells assessed as increase in cAMP production measured at 50 mins by ACTOn...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed