BDBM50250642 CHEMBL4095904::US10961200, Compound 95::US11247971, Cmpd ID 95

SMILES OC(=O)c1csc(n1)-n1nc(cc1O)-c1cc(F)cc(F)c1

InChI Key InChIKey=ISVTXETUDSDOCV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50250642   

TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250642(CHEMBL4095904 | US10961200, Compound 95 | US112479...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and in absence of EDTA by diaphorase/resazurin ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250642(CHEMBL4095904 | US10961200, Compound 95 | US112479...)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and in absence of EDTA by diaphorase/resazurin ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50250642(CHEMBL4095904 | US10961200, Compound 95 | US112479...)
Affinity DataIC50: 5.70E+4nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent