BDBM50269455 CHEMBL4087402

SMILES COc1cc(F)ccc1C1CN(CCN1)c1nc(cc(=O)n1C)-c1ccncc1

InChI Key InChIKey=RPIKXGUGTPFFLU-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50269455   

TargetGlycogen synthase kinase-3 beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human GSK-3beta using prephosphorylated GS-1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human GSK-3beta using prephosphorylated GS-1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant human GSK-3beta using prephosphorylated GS-1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of recombinant human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50269455(CHEMBL4087402)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2020
Entry Details Article
PubMed