BDBM50274994 CHEMBL4125840

SMILES CN1CCN(CC1)c1ccc(Nc2cc3c(N[C@H]4CCN(C4)C(=O)C=C)nc(Nc4ccccc4)nc3cn2)nc1

InChI Key InChIKey=WBTJOPXRJMWQAC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50274994   

TargetEpidermal growth factor receptor(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50274994(CHEMBL4125840)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50274994(CHEMBL4125840)
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50274994(CHEMBL4125840)
Affinity DataIC50: 238nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Xi'An Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50274994(CHEMBL4125840)
Affinity DataIC50: 500nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2020
Entry Details Article
PubMed