BDBM50279735 CHEMBL4173877

SMILES Clc1ccc2nc(nc(Nc3cc([nH]n3)C3CC3)c2c1)-c1cccc(c1)C#N

InChI Key InChIKey=UASKPELCJPQDEL-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50279735   

TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279735(CHEMBL4173877)
Affinity DataKi:  50nMAssay Description:Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279735(CHEMBL4173877)
Affinity DataKi:  200nMAssay Description:Inhibition of recombinant SRC (unknown origin) using polyE4Y as substrate by pyruvate kinase-lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279735(CHEMBL4173877)
Affinity DataKi:  750nMAssay Description:Inhibition of recombinant CDK2/cyclin A (unknown origin) using MAHHRSPRKRAKKK as substrate by pyruvate kinase-lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PknA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279735(CHEMBL4173877)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PknA (M1 to A296 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells using [T-33P]ATP as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50279735(CHEMBL4173877)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) using HSSPHQ(Sp)EDEEE as substrate by pyruvate kinase-lactate dehydrogenase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed