BDBM50296183 CHEMBL549433::cis-1-(3-(4-(3-ethyl-2,3-dihydrobenzo[b][1,4]oxathiin-2-yl)phenoxy)propyl)pyrrolidine

SMILES CC[C@@H]1Sc2ccccc2O[C@@H]1c1ccc(OCCCN2CCCC2)cc1

InChI Key InChIKey=YYOXBGHALUHPAP-JTHBVZDNSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50296183   

TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50296183(CHEMBL549433 | cis-1-(3-(4-(3-ethyl-2,3-dihydroben...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50296183(CHEMBL549433 | cis-1-(3-(4-(3-ethyl-2,3-dihydroben...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50296183(CHEMBL549433 | cis-1-(3-(4-(3-ethyl-2,3-dihydroben...)
Affinity DataIC50:  5.90nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50296183(CHEMBL549433 | cis-1-(3-(4-(3-ethyl-2,3-dihydroben...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed