BDBM50311927 CHEMBL1076437::N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(4-ethylpiperazin-1-yl)-5-(trifluoromethyl)benzamide

SMILES CCN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(Nc2nc3ccccc3n2-c2cc(N)ncn2)c1

InChI Key InChIKey=HTEUQPWFMDGLKN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50311927   

TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311927(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Tel-fused LCK expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311927(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Tel-fused KDR expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311927(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Tel-fused LYN expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311927(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 11nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311927(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 16nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311927(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 57nMAssay Description:Inhibition of Tel-fused SRC expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311927(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 71nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50311927(N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazo...)
Affinity DataIC50: 588nMAssay Description:Inhibition of Tel-fused InsR expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed