BDBM50315675 ((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-2-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone::CHEMBL1089103
SMILES C[C@H]1CN(C[C@@H](C)[C@]1(O)c1ccccc1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(F)cc1F)c1ccccn1
InChI Key InChIKey=CSQOOKHGXFRBEQ-MHMLHYMTSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50315675
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 4.70nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
Affinity DataKi: 79nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: >1.67E+4nMAssay Description:Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 71nMAssay Description:Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 960nMAssay Description:Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayMore data for this Ligand-Target Pair