BDBM50326286 (R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)phenylthio)ethyl)piperidine::CHEMBL1243395

SMILES FC(F)(F)c1ccc(SC[C@H](C2CCNCC2)c2cnc[nH]2)cc1

InChI Key InChIKey=HGLGWLWXYRAXPK-UHFFFAOYSA-N

Data  5 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50326286   

TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  48nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataEC50:  74nMAssay Description:Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  310nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed