BDBM50335162 3-[5-(2-Fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-aza-spiro[4.5]dec-2-ene::CHEMBL1650525

SMILES Fc1ccccc1-c1cc(c2[nH]c(nc2c1)C1=NOC2(C1)CCCCC2)C(F)(F)F

InChI Key InChIKey=FWMADLQTWXEZMO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50335162   

TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335162(3-[5-(2-Fluorophenyl)-7-trifluoromethyl-1H-benzimi...)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335162(3-[5-(2-Fluorophenyl)-7-trifluoromethyl-1H-benzimi...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed