BDBM50335512 1-(4-(5-benzylbenzo[d]thiazol-2-yl)-3-fluorobenzyl)azetidine-3-carboxylic acid::CHEMBL1651850

SMILES OC(=O)C1CN(Cc2ccc(-c3nc4cc(Cc5ccccc5)ccc4s3)c(F)c2)C1

InChI Key InChIKey=PVVUFYZWSRTSJA-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50335512   

TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335512(1-(4-(5-benzylbenzo[d]thiazol-2-yl)-3-fluorobenzyl...)
Affinity DataEC50:  1.21E+3nMAssay Description:Agonist activity at human S1P3R expressed in CHO cells by Ca(2+) mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335512(1-(4-(5-benzylbenzo[d]thiazol-2-yl)-3-fluorobenzyl...)
Affinity DataEC50:  41nMAssay Description:Induction of human GFP-tagged chimeric S1P1R internalization in human U2Os cells by fluorescence microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335512(1-(4-(5-benzylbenzo[d]thiazol-2-yl)-3-fluorobenzyl...)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human S1P1 receptor expressed in U20S cells coexpressing eGFP assessed as receptor internalization after 1 hr by microscopy analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335512(1-(4-(5-benzylbenzo[d]thiazol-2-yl)-3-fluorobenzyl...)
Affinity DataEC50:  42nMAssay Description:Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335512(1-(4-(5-benzylbenzo[d]thiazol-2-yl)-3-fluorobenzyl...)
Affinity DataEC50:  1.21E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO cells coexpressing Gq/i5 protein by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50335512(1-(4-(5-benzylbenzo[d]thiazol-2-yl)-3-fluorobenzyl...)
Affinity DataEC50:  1.21E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed