BDBM50337604 CHEMBL1683059::Cis-((1S,3R)-1-isopropyl-3-(3-methyl-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone

SMILES CC(C)[C@@]1(CC[C@H](C1)N[C@H]1CCOC[C@H]1C)C(=O)N1CCN(CC1)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=NMYCPGLFRHGTSV-ASASOQJESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50337604   

TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50337604(CHEMBL1683059 | Cis-((1S,3R)-1-isopropyl-3-(3-meth...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50337604(CHEMBL1683059 | Cis-((1S,3R)-1-isopropyl-3-(3-meth...)
Affinity DataIC50:  77nMAssay Description:Displacement of labeled MIP-1beta from human CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50337604(CHEMBL1683059 | Cis-((1S,3R)-1-isopropyl-3-(3-meth...)
Affinity DataIC50:  3.10nMAssay Description:Displacement of [125I]MCP1 from human CCR2 after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed