BDBM50372153 CHEMBL255955

SMILES Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c12

InChI Key InChIKey=LYHXSDWIWVVZPB-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50372153   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  5nMAssay Description:Inhibition of FLT1 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  7nMAssay Description:Inhibition of cKit by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  3nMAssay Description:Inhibition of CSF1R by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of KDR kinase activity (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of FYN by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of KDR (unknown origin) in cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of KDR kinase activity (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of KDR (unknown origin) in cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50372153(CHEMBL255955)
Affinity DataIC50:  2nMAssay Description:Inhibition of FLT3 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed