BDBM50381748 CHEMBL2022656

SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=Cc5c(C[C@]34C)cnn5-c3ccccc3)[C@@H]1CC[C@]2(O)C(=O)CSc1nc2ncccc2o1

InChI Key InChIKey=AAFYPWXCJRYVKV-ILTCGSTDSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50381748   

TargetGlucocorticoid receptor(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50381748(CHEMBL2022656)
Affinity DataIC50:  33.8nMAssay Description:Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as induction of tyrosineaminotransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50381748(CHEMBL2022656)
Affinity DataIC50:  0.890nMAssay Description:Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-induced IL8 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50381748(CHEMBL2022656)
Affinity DataIC50:  37.7nMAssay Description:Transactivation activity at glucocorticoid receptor in human HepG2 cells assessed as induction of tyrosineaminotransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50381748(CHEMBL2022656)
Affinity DataIC50:  6.90nMAssay Description:Transactivation activity at human glucocorticoid receptor in cells co-expressing GRE by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed