BDBM50393282 CHEMBL2139663

SMILES Cc1ccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)cc1

InChI Key InChIKey=XXSFXQLMBCXBAH-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393282   

TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM50393282(CHEMBL2139663)
Affinity DataEC50:  4.58E+3nMAssay Description:Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM50393282(CHEMBL2139663)
Affinity DataEC50:  2.60E+3nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM50393282(CHEMBL2139663)
Affinity DataEC50:  1.19E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed